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TP1277 |
Bradykinin
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Endogenous Metabolite
,
Bradykinin Receptor
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Bradykinin is an inflammatory mediator. It is a peptide that causes blood vessels to dilate (enlarge) via the release of prostacyclin, nitric oxide, and Endothelium-Derived Hyperpolarizing Factor. Bradykinin is a physiol... |
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T7017 |
WNK463
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Serine/threonin kinase
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WNK463 is a pan-WNK-kinase inhibitor. It effectively inhibits the in vitro kinase activity of all four WNK family members (WNK1/2/3/4). |
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T11666 |
IPR-803
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Serine/threonin kinase
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IPR-803 is an effective inhibitor of the uPAR·uPA protein-protein interaction (PPI) with anti-tumor activity. IPR-803 binds directly to uPAR with a Ki of 0.2 μM. |
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T11885 |
LSP-249
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Others
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LSP-249 is a plasma kallikrein inhibitor under the study for angioedema, with an EC50 less than 100 nM in cell. |
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T4058 |
R-IMPP
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Others
,
Serine/threonin kinase
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R-IMPP is an inhibitor of PCSK9 translation. R-IMPP stimulates uptake of LDL-C in hepatoma cells by increasing LDL-R levels, without altering levels of secreted transferrin. |
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T10547 |
BioE-1115
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Serine/threonin kinase
,
Casein Kinase
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T13257 |
Upamostat
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PAI-1
,
Serine/threonin kinase
,
Serine Protease
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Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor. |
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T9920 |
Evolocumab
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Others
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Evolocumab is a human IgG2 monoclonal antibody that binds to human PCSK9 Proprotein Convertase Subtilisin Kexin Type 9). |
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T4524 |
SBC-110736
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SBC110736 |
Others
,
Serine/threonin kinase
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SBC-110736 is a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor |
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T8350 |
TPCK
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Proteasome
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TPCK is an irreversible inhibitor of chymotrypsin-like proteases that affect cell proliferation, apoptosis, and tumorigenesis |
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T14358 |
Avoralstat
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BCX4161 |
Others
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Avoralstat (BCX4161) is an oral plasma kallikrein (PKK) inhibitor. Which is used for the treatment of hereditary angioedema. |
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T9276 |
SBC-115337
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Others
,
Serine/threonin kinase
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SBC-115337 is a PCSK9 inhibitor. |
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T8645 |
PF-06446846
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Others
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PF 06446846 is a potent and selective PCSK9 inhibitor |
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T2626 |
SBC-115076
|
SBC115076 |
Others
,
Serine/threonin kinase
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SBC-115076 is a potent extracellular proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist. |
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T8676 |
FOY 251
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Others
,
Serine/threonin kinase
,
SARS-CoV
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FOY 251 is a proteinase inhibitor, and is an anti-proteolytic active metabolite camostate. |
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T5456 |
WNK-IN-11
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Allosteric WNK Kinase Inhibitor |
Serine/threonin kinase
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WNK-IN-11 (Allosteric WNK Kinase Inhibitor) is an allosteric With-No-Lysine (WNK) kinase inhibitor,WNK1(IC50 : 4 nM) |
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T8362 |
Benzamidine hydrochloride
|
Benzamidine HCl |
Serine/threonin kinase
,
Serine Protease
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Benzamidine hydrochloride (Benzamidine HCl) is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Ki of 35, 350, and 220 μM, respectively). |
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T6370 |
AEBSF hydrochloride
|
AEBSF HCl,Pefabloc SC |
Thrombin
,
Serine Protease
,
Influenza Virus
|
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AEBSF hydrochloride (Pefabloc SC) is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, thrombin, plasmin, and trypsin. |
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T13408 |
ZK824190
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Others
,
Serine Protease
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ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA) as a potential treatment for multiple sclerosis(IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively). |
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T3359 |
Aprotinin
|
Bovine Pancreatic Trypsin Inhibitor,Traskolan,Antilysin |
Others
,
Serine Protease
,
Influenza Virus
,
Proteasome
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Aprotinin (Traskolan) a broad-spectrum serine protease inhibitor, inhibiting the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activat... |
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T2392 |
Nafamostat mesylate
|
FUT-175 |
Apoptosis
,
Serine/threonin kinase
,
SARS-CoV
,
Serine Protease
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Nafamostat mesylate (FUT-175), a synthetic serine protease inhibitor, has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis. |
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T31206 |
Darexaban
|
YM 150,Darexaban, Tanexaban,YM150 |
Factor Xa
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Darexaban (Tanexaban, YM-150) is a direct inhibitor of Factor Xa.Darexaban and Darexaban glucuronide selectively and competitively inhibit FXA and inhibit prothrombin activity at the site of blood clot (thrombus) formati... |
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T19763 |
Cetraxate hydrochloride
|
DV-1006,DV 1006,Cetraxate HCl,DV1006 |
Serine/threonin kinase
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Cetraxate hydrochloride (DV10062) is an oral gastrointestinal medication. It has a cytoprotective effect. |
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T8936 |
Proteinase K
|
proteinase K for tritirachium album,Protease K |
Others
|
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Proteinase K (proteinase K for tritirachium album) is a nonspecific serine protease that is useful for general digestion of proteins. It is active in the presence of SDS or urea and over a wide range of pH (4-12), salt c... |
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T2391 |
Camostat mesylate
|
FOY-S980,FOY305,Camostat mesilate |
Serine/threonin kinase
,
SARS-CoV
,
Sodium Channel
|
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Camostat mesylate (FOY-S980) is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function. |
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T80094 |
Dansyl-Glu-Gly-Arg-Chloromethylketone
|
|
|
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Dansyl-Glu-Gly-Arg-Chloromethylketone is a protease inhibitor that specifically impedes serine/threonine proteases and has been shown to inhibit activated porcine factor IX [1]. |
